Macrocytose, polyneuropathie en achterstrengstoornissen door malabsorptie van eiwitgebonden vitamine B12

Macrocytosis, polyneuropathy and posterior column disorders due to malabsorption of protein-bound vitamin B₁₂. – This case report concerns a patient with a vitamin B₁₂ deficiency and a normal Schilling test, who had macrocytosis of many years‘ duration and finally polyneuropathy. All known causes of a vitamin B₁₂ deficiency were excluded. When the Schilling test was performed with egg consumption, excretion of vitamin B₁₂ was clearly diminished. It appears highly likely that this vitamin B₁₂ deficiency developed as a result of malabsorption of protein-bound vitamin B₁₂.