Incidentie en beloop van het complex regionaal pijnsyndroom type 1*

Limited data are available on the incidence of CRPS1, and on demographic and medical risk factors for the development of CRPS1. The objective of this study is to investigate the incidence of CRPS1 in patients with a fracture using three sets of diagnostic criteria, and to evaluate the association between demographic/medical factors and the development of CRPS1 diagnosed with the Harden/Bruehl criteria. A prospective multicenter cohort study of 596 patients (aged 18 years and older) with a single fracture of the wrist, hand, foot or ankle, recruited from the emergency rooms of three Dutch hospitals. Of the 596 participants 42 (7.0%) were diagnosed with CRPS1 according to the (full) criteria of Harden/Bruehl, 289 (48.5%) according to the IASP criteria, and 127 (21.3%) according to the criteria of Veldman. An analysis of the medical and demographic differences revealed that patients who later developed CRPS1 had significantly more often an intra-articular fracture, rheumatoid arthritis, musculoskeletal comorbidities or fracture dislocation. An ankle fracture, dislocation and an intra-articular fracture contributed significantly to the prediction of the development of CRPS1. No CRPS1 patients were symptom free at 12 months (T3). At baseline, patients with CRPS1 had significantly more pain than patients without CRPS1 (p

Conflict of interest: none declared. Financial support: A. Beerthuizen received a research subsidy from the Foundation Erasmus Pain Fighting Fund (Stichting Erasmus Fonds Pijnbestrijding), Erasmus MC Rotterdam.