Tranexaminezuur: breed toepasbaar, weinig risico’s

• Tranexamic acid is a cheap and easy to use drug for the treatment and prevention of bleeding.
• In the past, its use was mainly empiric and primarily in patients with coagulation disorders.
• More recently, large scale randomized controlled trials have shown that tranexamic acid reduces mortality in women with postpartum hemorrhage and in victims of trauma.
• In a number of surgical settings, including cardiothoracic and orthopedic, tranexamic acid reduces bleeding complications.
• In these studies, there was no signal of increased risk of thrombosis. Tranexamic acid is also effective in reducing heavy menstrual bleeding, the prevention of bleeding after dental interventions and a number of other high-prevalence conditions.
• There are no data that support an increased risk of thrombosis when patients without haemostatic disorders use tranexamic acid for a longer period, but addition studies would be helpful.
• Finally, the topical administration of the drug for mucocutaneous nuisance bleeds deserves more attention.

Conflict of interest and financial support: potential conflicts of interest have been reported for this article. ICMJE forms provided by the authors are available online along with the full text of this article.