Kiembaanmodificatie: waarom mag het niet?

Germline gene editing makes it possible to modify genetic predisposition during early human life. In precursor cells of oocytes or sperm, or in embryos soon after conception, the technique of CRISPR could be used to repair predisposition for inherited diseases. European legislation does not allow modification of the genome of the next generation, because this is about modifying genetic identity. There seems to be a fundamental principle that one has to become who one is predisposed to be. As long as there is no certainty with respect to the safety and effectiveness of germline gene editing, its use for the next generation is premature. However, the fundamental principle that genetic identity should not be modified in the germline is of a deterministic nature and goes against current views on identity, autonomy and doing good.

Conflict of interest and financial support: none declared.