Overgevoeligheidsreacties en vaccins

• A lot of questions are being asked in the Netherlands about the safety of vaccination. More knowledge among care providers helps with regard to good medical practice and information.
• Severe hypersensitivity reactions to vaccines are rare. Chicken-egg protein, gelatine and thiomersal are the most important vaccine components that may provoke severe reactions.
• Acute treatment of patients with severe hypersensitivity reactions consists of intramuscular adrenaline.
• In case of a severe reaction to a vaccine or a vaccine component, the subsequent course of action is determined by the physician referred to: the allergist or paediatric allergist. For most patients, vaccination or revaccination is possible in a setting where acute treatment is possible.
• Slight side effects and delayed hypersensitivity reactions are not good reasons for additional measures with respect to vaccination.
• It is important to record hypersensitivity reactions completely and unambiguously in the patient file.

Conflict of interest and financial support: potential conflicts of interest have been reported. ICMJE forms provided by the authors are available online along with the full text of this article.